fbpx

– Löfberg L (2018) Voiko pelimuotoisilla kognitiivisilla harjoitteilla edesauttaa muistipotilaiden toimintakykyä?

– George Savulich, PhD; Thomas Piercy, BSc; Chris Fox, MD, MRCPsych; John Suckling, PhD; James B. Rowe, PhD; John T. O’Brien, DM; FMedSci, Barbara J. Sahakian, DSc, FMedSci (2017) Cognitive training using a novel memory game on iPad in patients with Amnestic Mild Cognitive impairment (aMCI). International journal of Neuropsychopharmacology (2017) 20(8): 624-633.

– Djabelkhir L, Wu YH, Vidal JS, Cristancho-Lacroix, V, Marlats F, Lenoir H, et al. Computerized cognitive stimulation and engagement programs in older adults with mild cognitive impairment: comparing feasibility, acceptability, and cognitive and psychosocial effects. Clinical Interventions in Aging 2017;12:1967–75. 

Lievästä kognitiivisesta heikentymisestä (MCI) kärsivät henkilöt joko tekivät kolme kuukautta joko tietokoneavusteista kognitiivista harjoittelua (koeryhmä) tai opettelivat uusia tietotekniikkataitoja (kontrolliryhmä). Koeryhmän suorituskyky kognitiivista toiminnanohjausta mittaavassa Trail making testissä parani enemmän kuin kontrolliryhmässä.

– Fiatarone Singh MA, Gates N, Saigal N, Wilson GC, Meiklejohn J, Brodaty H, et al. The Study of Mental and Resistance Training (SMART) study-resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial. Journal of the American Medical Directors Association 2014; 15(12):873–80.

Verrattiin sekä 6 kk kestävän lihaskuntoharjoittelun (intensiivinen treeni vs. venyttely) ja tietokoneavusteisen kognitiivisen harjoittelun (intensiivinen harjoittelu vs. pelkkä viihdekäyttö) vaikutuksia kognitiiviseen toimintaan. Kognitiivinen harjoittelu loivensi ajan myötä tapahtuvaa muistin heikkenemistä. (Lihaskuntoharjoittelusta oli enemmän hyötyä, verrattuna venyttelyyn, lihaskuntoharjoittelu paransi yleistä kognitiota huomattavasti).

– Gooding AL, Choi J, Fiszdon JM, Wilkins K, Kirwin PD, van Dyck CH, et al. Comparing three methods of computerised cognitive training for older adults with subclinical cognitive decline. Neuropsychological Rehabilitation 2016;26(5-6):810–21.

16 viikon tietokoneavusteinen kognitiivinen harjoittelu nosti yleisen kognition pistemäärää kontrolliryhmään verrattuna.

– Herrera C, Chambon C, Michel BF, Paban V, Alescio-Lautier B. Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia 2012;50(8):1871–81.

Koeryhmän koehenkilöiden muistitoiminnot paranivat 12 viikon harjoittelujakson myötä kontrolliryhmää enemmän. Vaikutus oli havaittavissa vielä 6 kuukautta intervention jälkeen.

Bamidis, P. D., Fissler, P., Papageorgiou, S. G., Zilidou, V., Konstantinidis, E. I., Billis, A. S., Romanopoulou, E., Karagianni, M., Beratis, I., Angeliki, T., Tsilikopoulou, G., Grigoriadou, E., Ladas, A., Kyrillidou, A., Tsolaki, A., Frantzidis, C., Sidiropoulos, E., Siountas, A., Matsi, S., Papatriantafyllou, J., Margioti, E., Nika, A., Schlee, W., Elbert, T., Tsolaki, M., Vivas, A. B. & Kolassa I. (2015) Gains in cognition through combined cognitive and physical training: the role of training dosage and severity of neurocognitive disorder. Front Aging Neurosci., 7:152.

Mura, G., Carta, M. G., Sancassiani, F., Machado, S. & Prosperini, L. (2017) Active exergames to improve cognitive functioning in neurological disabilities: a systematic review and meta-analysis. Eur J Phys Rehabil Med., DOI: 10.23736/S1973-9087.17.04680-9.

Rinne, J., Rosenvall, A., Erkinjuntti, T., Koponen, H., Löppönen, M., Raivio, M., Strandberg, T., Vanninen, R., Vataja, R., Tuunainen, A., Hartikainen, S., Hietanen, M., Hänninen, T., Kivipelto, M., Melkas, S., Ojala, M., Pitkälä, K., Voutilainen, P. (2017) Suomalaisen Lääkäriseuran Duodecimin, Societas Gerontologica Fennican, Suomen Geriatrit -yhdistyksen, ja Suomen Yleislääketieteen yhdistyksen asettama työryhmä. Muistisairaudet (online). Käypä hoito -suositus. Helsinki: Suomalainen Lääkäriseura Duodecim, 133 (8),756-7.

Stanmore, E., Stubbs, B., Vancampfort, D., de Bruin, E. D. & Firth, J. (2017) The effect of active video games on cognitive functioning in clinical and non-clinical populations: A meta-analysis of randomized controlled trials. Neurosci Biobehav Rev., 78: 34-43.

Wiloth, S., Werner, C., Lemke, N. C., Bauer, J. & Hauer, K. (2017) Motor-cognitive effects of a computerized game-based training method in people with dementia: a randomized controlled trial. Aging Ment Health., DOI: 10.1080/13607863.2017.1348472

Oxford: Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox

NC, Gamst A, Holtzman DM, Jagust WK, Petersen RC, Snyder

PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild

cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging and Alzheimer’s Association workgroup. Alzheimers Dement 7:270–279.

Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J, Kong E, Larraburo Y, Rolle C, Johnston E, Gazzaley A

(2013) Video game training enhances cognitive control in older adults. Nature 501:97–101.

Barnett JH, Blackwell AD, Sahakian BJ, Robbins TW (2016) The Paired Associates Learning (PAL) test: 30 years of CANTAB

Translational Neuroscience from Laboratory to Bedside in Dementia Research. In: Current topics in behavioral neuroscience: translational neuropsychopharmacology (Robbins TW, Sahakian BJ, eds), vol. 28, pp. 449–474.

Beddington J, Cooper CL, Field J, Goswami U, Huppert FA, Jenkins R, Jones HS, Kirkwood TB, Sahakian BJ, Thomas SM (2008) The

mental wealth of nations. Nature 455:1057–1060.

Belleville S (2008) Cognitive training for persons with mild cognitive impairment. Int Psychogeriatr 20:57–66.

Benedict RH (1997) Brief visuospatial test-revised: professional manual. Odessa, FL: PAR.

Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins, TW, Hodges JR (2004) Detecting dementia: novel neuropsychological markers of preclinical Alzheimer’s disease. Dement Geriatr Cogn Disord 17:42–48.

Brühl A, Sahakian BJ (2016) Drugs, games, and devices for enhancing cognition: implications for work and society. Ann N Y Acad Sci 1369:195–217.

Buettner LL, Fitzsimmons S, Atav S, Sink K (2011) Cognitive stimulation for apathy for probable early-stage Alzeimer’s. J Aging Res 480890.

Collins PY et al. (2011) Grand challenges in global mental health.

Nature 475:27–30.

DeCarli C (2003) Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment. Lancet Neuol 2:15–21.

de Rover M, Pironti VA, McCabe JA, Acosta-Cabronero J, Sergio Arana F, Morein-Zamir S, Hodges JR, Robbins TW, Fletcher PC,

Nestor PJ, Sahakian BJ (2011). Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task. Neuropsychologia 49:2060–2070.

Dickerson BC, Sperling RA (2008) Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer’s disease: insights from functional MRI studies. Neuropsychologia 46:1624–1635.

Eagger SA, Levy R, Sahakian BJ (1992) Tacrine in Alzheimer’s disease. Acta Neurol Scand Suppl 139:75–80.

Feldman HH et al (2007) Effect of rivastigmine on delay to diagnosis of Alzheimer’s disease from mild cognitive impairment: the InDDEx study. Lancet Neurol 6:501–512.

Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”.

A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198.

Gates NJ, Sachdev PS, Fiatarone Singh MA, Valenzuela M (2011)

Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr 11:55.

Huntley JD, Gould RL, Liu K, Smith M, Howard RJ (2015) Do cognitive interventions improve general cognition in dementia?

A meta-analysis and meta-regression. BMJ Open 5:e005247.

Insel TR, Sahakian BJ (2012) Drug research: a plan for mental illness. Nature 483:269.

Insel TR, Voon V, Nye JS, Brown VJ, Altevogt BM, Bullmore ET, Goodwin GM, Howard RJ, Kupfer DJ, Malloch G, Marston HM, Nutt DJ, Robbins TW, Stahl SM, Tricklebank MD, Williams JH, Sahakian BJ (2013). Innovative solutions to novel drug development in mental health. Neurosci Biobehav Rev 37:2438–2444.

Jean L, Bergeron ME, Thivierge S, Simard M (2010) Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr

Psychiatry 18:281–296. Kaser M, Deakin JB, Michael A, Zapata C, Bansal R, Ryan D, Cormack F, Rowe JB, Sahakian BJ (2016) Modafnil improves episodic memory and working memory cognition in patients with remitted depression: a double-blind, randomized, placebo-controlled study. Biol Psychiatry Cogn Neurosci Neuroimaging 2:115–122.

Kirchhoff BA, Anderson BA, Smith SE, Barch DM, Jacoby LL (2012)

Cognitive training-related changes in hippocampal activity associated with recollection in older adults. Neuroimage

62:1956–1964.

Li H, Li J, Li N, Li B, Wang P, Zhou T (2011) Cognitive intervention for persons with mild cognitive impairment: a meta-analysis.

Ageing Res Rev 10:285–296.

Manera V, Petit P-D, Derreumaux A, Orvieto I, Romagnoli M, Luttle G, David R, Robert PH (2015) ‘Kitchen and cooking,’ a serious game for mild cognitive impairment and Alzheimer’s disease: a pilot study. Front Aging Neurosci 17:7–24.

Marin RS (1996) Apathy: concept, syndrome, neural mechanisms, and treatment. Semin Clin Neuropsychiatry 1:304–314.

Martin M, Clare L, Altgassen AM, Cameron MH, Zehender F (2011)

Cognition-based interventions for healthy older people and

people with mild cognitive impairment. Cochrane Database

Syst Rev 19:CD006220.

Moher D, Schulz KF, Atlman DG (2001) The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trails. Lancet 357:1191– 1194.

Monastero R, Mangialasche F, Camarda C, Ercolani S, Camarda R

(2009) A systematic review of neuropsychiatric symptoms in mild cognitive impairment. J Alzheimers Dis 18:11–30.

Nathan PJ, Ying Lim Y, Abbott R, Galluzzi S, Marizzoni M, Babiloni C, et al. (2017) Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). Neuobiol Aging

53:1–10.

Nelson HE (1982) National Adult Reading Test (NART): for the assessment of premorbid intelligence in patients with dementia: test manual. Windsor, UK: NFER-Nelson.

Petersen RC (2011) Clinical practice. Mild cognitive impairment.

N Engl J Med 364:2227–2234.

Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris

S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck

CH, Thal LJ (2005) Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352:2379–2388.

Reijnders J, van Heugten C, van Boxtel M (2013) Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review. Ageing Res Rev

12:263–275.

Rosen AC, Sugiura L, Kramer JH, Whitfeld-Gabrieli S, Gabrieli

JD (2011) Cognitive training changes hippocampal function in Mild Cognitive Impairment: a pilot study. J Alzheimers Dis

26:349–357.

Sahakian BJ (2014) What do experts think we should do to achieve brain health? Neurosci Biobehav Rev 43:240–258.

Sahakian BJ, Morris RG, Evenden JL, Heald A, Levy R, Philpot M, Robbins TW (1988) A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson’s disease. Brain 111:695–718.

Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S,

Crayton L, Crockford HA, Crooks M, Hill K, Levy R (1993) Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer’s disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology (Berl) 110:395–401.

Sahakian BJ et al. (2010) A UK strategy for mental health and wellbeing. Lancet 375:1854–1855.

Sahakian BJ, Brühl AB, Cook J, Killikelly C, Savulich G, Piercy T,

Hafzi J, Perez J, Fernandez-Egea E, Suckling J, Jones PB (2015)

The impact of neuroscience on society: cognitive enhancement in neuropsychiatric disorders and in healthy people.

Philos Trans R Soc Lond B Biol Soc 370:20140214.

Savulich G, Piercy T, Brühl AB, Fox C, Suckling J, Rowe JB, O’Brien

JT, Sahakian BJ (2017) Focusing the neuroscience and societal implications of cognitive enhancers. Clin Pharmacol Ther

101:170–172.

Sheikh JI, Yesavage JA (1986) Geriatric Depression Scale (GDS):

recent evidence and development of a shorter version. Clinical gerontology: a guide to assessment and intervention,

pp165–173, New York: The Haworth Press.

Simon SS, Yokomizo JE, Bottino CM (2012) Cognitive intervention in amnestic mild cognitive impairment: a systematic review.

Neurosci Biobehav Rev 36:1163–1178.

Strenziok M, Parasuraman R, Clarke E, Cisler DS, Thompson JC,

Greenwood PM (2014) Neurocognitive enhancement in older adults: comparison of three cognitive training tasks to test a

hypothesis of training transfer in brain connectivity. Neuroimage 85:1027–1039.

Swainson R, Hodges JR, Galton CJ, Semple J, Michael A, Dunn BD,

Iddon JL, Robbins TW, Sahakian BJ (2001) Early detection and differential diagnosis of Alzheimer’s Disease and depression

with neuropsychological tasks. Dement Geriatr Cogn Disord

12:265–280.

Winblad B, Gauthier S, Scinto L, Feldman H, Wilcock GK, Truyen

L, Mayorga AJ, Wang D, Brashear HR, Nye JS (2008) Safety and effcacy of galantamine in subjects with mild cognitive

impairment. Neurology 70:2024–2035.

World Health Organization (April 2016). Dementia. Available at http://www.who.int/mediacentre/factsheets/fs362/en/.

Accessed January 2, 2017.

Wykes T, Huddy V, Cellard C, McGurk SR, Czobor P (2011) A metaanalysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry 168:472–485.

Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370.